disorders (blood clotting factors)
and treatment of hemorrhagic disease in newborn
K deficiency is
may develop hypervitaminosis K with excessive intravenous dosages.
Symptoms of hypervitaminosis are flushing sensations,
taste changes and rarely, dizziness sweating and rapid and weak pulse.
K will NOT reverse the anticoagulant effects of heparin.
of coumarin class (warfarin) anticoagulation takes from 1-2 hours.
K is excreted into breast milk.
Reactions (Side Effects):
non-toxic in therapeutic doses
in newborns, occurring at doses greater than recommended.
sources: pork, liver, green leafy vegetables (spinach, broccoli), GI
flora can produce from diet
in oral soft gelatin capsules or injection
supplementation (RDA: recommended daily allowance):
prothrombin deficiency: 2.5-10mg per day (up to 25mg initially)
disease in newborn:
single IM dose 0.5-1mg within 1 hour of birth, may repeat in 2-3
weeks. Mother may
receive 1-5mg 12-24 hours before delivery.
Oral doses of 2mg are adequate.
1mg SQ or IM, in conjunction with proper laboratory testing of PT.